Collaborative Cohort of Cohorts for COVID-19 Research
The primary objectives for Phase 1 of the study are to 1) ascertain SARS-CoV-2 infection and COVID-19 illness by standardized questionnaires, events adjudication and serology in order to generate a community-based estimate of the incidence of COVID-19 events and an inception cohort of COVID-19 cases relatively free of referral and disease spectrum biases; 2) harmonize COVID- 19 outcomes and other relevant phenotyping across the cohorts; and 3) plan for a potential Phase 2 cross-study COVID-19 cohort for repeat measures.
Participants in C4R are currently enrolled in 14 long-term cohort studies and range in age from young adulthood to elderly and reflect the racial/ethnic, socioeconomic, and geographic diversity of the United States.
If we conservatively estimate ascertainment in only 85% of the C4R contact target, there will be 90% power in C4R to detect an odds ratio of 1.68 per standard deviation of a continuous risk factor with respect to an event occurring in only 0.10% of participants.
Phase 1 will last 2 years and include 3 waves of questionnaires.