Passive Immunity Trials

Clinical Trial of COVID-19 Convalescent Plasma in Outpatients

  • Clifton W. Callaway
    University of Pittsburgh Medical Center, (Study PI, CCC Co-PI)
  • Valerie Durkalski-Mauldin
    Medical University of South Carolina, (Study Co-PI, DCC-PI)
  • Frederick Korley
    University of Michigan, (Study Co-PI)

The overarching goal of this project is to confirm or refute the role of passive immunization as a safe and efficacious therapy in preventing the progression from mild to severe/critical COVID-19 illness and to understand the immunologic kinetics of anti-SARS-CoV-2 antibodies after passive immunization.The primary objective is to determine the efficacy and safety of a single dose of convalescent plasma (CP) for preventing the progression from mild to severe COVID-19 illness. The secondary objective is to characterize the immunologic response to CP administration.

Vitalant is collecting plasma from people who have recovered from COVID-19. Called “convalescent plasma,” it contains antibodies to the SARS-CoV-2 coronavirus, which can be given to patients currently fighting COVID-19. Learn More

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Therapeutics for Inpatients with COVID-19 (TICO)

  • Dr. Annetine Gelijns
    Mount Sinai – CC PI
  • Dr. Alan Moskowitz
    Mount Sinai – CC mPI
  • Dr. Taylor Thompson
    Harvard – ICC PI
  • Katie Oldmixon
    Harvard – ICC Project Manager

TICO (Therapeutics for Inpatients with COVID-19) is a master protocol to evaluate the safety and efficacy of multiple investigational agents aimed at modifying the host immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, or directly enhancing viral control in order to limit disease progression.