The National Heart, Lung, and Blood Institute (NHLBI) provides global leadership for research, training, and education programs to enhance the health of individuals around the world. NHLBI is responsible for providing recommendations on CONNECTS developments and technical collaboration, as well as reviewing program milestones, objectives, and deliverables.https://www.nhlbi.nih.gov
Administrative Coordinating Center (ACC)
The Administrative Coordinating Center (ACC) is run by RTI International with assistance from the Vanderbilt Institute for Clinical and Translation Research. The ACC supports the project management, administration, and coordination needs of CONNECTS and provides expertise in areas of study design and standardization of data collection. The ACC is responsible for tracking milestones and streamlining clinical trials operations, oversight, and safety.
Vanderbilt Institute for Clinical and Translation Research (VICTR)
Vanderbilt Institute for Clinical and Translation Research (VICTR) is Vanderbilt's virtual home for clinical and translational research. The mission of the institute is to transform the way ideas and research discoveries make their way from origin to patient care.https://victr.vumc.org
NHLBI Biodata Catalyst
BioData Catalyst accelerates research and engagement to drive the discovery of new diagnostics, treatments, and prevention strategies. It supports data democratization, so NHLBI data is accessible and understandable by researchers and citizen scientists as they work to accelerate discovery.https://biodatacatalyst.nhlbi.nih.gov
Collaborating Networks and Groups
While these networks were originally created for different purposes, they have all refocused a substantial portion of their efforts to help conduct studies of COVID-19 therapeutics. The number of participating networks continues to grow, and are listed alphabetically.
The National Patient-Centered Clinical Research Network (PCORnet) supports patient-centered and data enabled clinical research to deliver results more efficiently and with greater power than previously possible by harnessing the power of health information (EHRs, claims data, registry data).https://pcornet.org
Participating members of the PCORnet network:
The mission of INSIGHT (International Network for Strategic Initiatives in Global HIV Trials) is to define optimal strategies for the management of HIV and other infectious diseases through a global clinical research network.http://insight.ccbr.umn.edu
The OneFlorida Clinical Research Consortium, a statewide clinical research network and database, aims to unite researchers, clinicians, patients and stakeholders to address some of the nation’s biggest health challenges and serve as a resource for the state in facilitating health care research and improving health, health care and health policy.https://onefloridaconsortium.org
Research Action for Health Network (REACHnet) is a partnership of health systems, academic centers, and public health organizations that constitute an innovative data network for conducting efficient, multi-site research.https://reachnet.org
The Venous thromboEmbolism Network United States (VENUS) is a collaborative US research network organized to initiate and implement collaborative, multi-institutional, investigator-initiated clinical trials and/or other scientific research projects focused on thrombotic disorders.https://www.invent-vte.com/network-members/member/~703-VENUS
Participating members of the VENUS network:
RAPID COVID COAG is a network of over 40 sites in the US, Canada, Ireland, Brazil, Saudi Arabia, and Serbia conducting a parallel pragmatic multi-center open-label randomized controlled trial to determine the effect of therapeutic anticoagulation compared to standard care in hospitalized patients with COVID-19 and an elevated D-dimer.